Hello Gavin,
Have been through the steps you suggested (some several times, and have also installed .NET Framework 4.5.2 from the Windows link), but am sorry to report without progress.
After restarting my laptop, starting Cymatic Trader, I entered the email and activation code in the License Activation Form. After a short while it returned the message "Activation results already completed in this computer" I selected OK then close, and then went to the login options.
Previously, I've been able to login in using the Minimal Login, but this returned the same message as yesterday, (as per attached screen shot Cymatic Minimal Login.JPG).
I then tried the Standard Login which returned a similar error message with connection issue dialogues (screenshot Cymatic Standard Login.JPG). I can confirm that the SSL and TLS boxes are checked.
Shortly after the above message a security alert message also appeared (screenshot Cymatic Security Alert.JPG).
The version of Vista I'm using is Home premium 32-Bit SP2, with Internet Explorer 9 - version:9.0.8112.16421 [update versions RTM (KB982861)]
I access the Internet via my mobile phone wireless hotspot, which is working fine for all other applications on the laptop, including Chrome, and also on a tablet.
Hopefully that makes sense, and there's at least some interim solution before I eventually upgrade my system.
Kind Regards David.
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